ABSTRACT
Developing an automated clean-in-place (CIP) recipe is a challenging activity for project such as a new facility, equipment or wing addition to an existing facility, a new product, or optimizing a legacy cleaning process. This article will focus on developing the automated CIP process for a new facility, but most of the information shared will be useful for all types of cleaning development projects for CIP automated cleaning systems. Semi-automated and manual cleaning applications have either different or additional pitfalls and challenges.
There are several reasons why developing a CIP cycle prior to cleaning validation is often a struggle:
1. High construction management company expectations
2. Non-optimal detergent selection
3. Trusting in legacy cleaning processes
4. Pre-development trail preparedness
5. Weak or non-existent CIP system review
6. Minimalist sampling plan
7. Interdepartmental miscommunication
8. Long lead times
In addition to discussing each reason in detail, the article offers solutions and best practices; so, a CIP cleaning process can be developed with confidence and minimal issues.
